Microspheres are small spherical particles, with diameters in the micrometer range typically 1 μm to 1000 μm. Microspheres are sometimes referred as micro particles. Microspheres form homogeneous, monolithic particles which improve the treatment by providing localization of the drug at the site of action and by prolonging the drug release. The objective of the present study was to formulate sustained release microspheres of tramadol hydrochloride using egg albumin as release retarding agent. From FTIR studies it was conformed that no interactions were found between TH and polymers. The maximum yield of the microspheres was found to be 96.99% and the encapsulation efficiency was found to be 65.2%. The prepared albumin microspheres released the drug completely within 7 hours at lower drug to polymer ratio. At ratio of more than 1:2, the drug release was sustained over a period of 10 hours. The microspheres were discrete, spherical and uniform in shape. The particle size was of the microspheres was found to be 99.6 μm. The prepared microspheres showed minor changes in particle size only under stability study with no appreciable change in drug content proving good stability of the product conducted in accelerated condition. The present study signifies the utility of microspheres in retarding the drug release. This may in turn reduces the frequency of dosing, thereby improving the patient compliance.
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